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In recent decades, a concerning decline in testosterone levels among men has been observed, potentially linked to dietary and lifestyle factors (13)

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methotrexate is a folic acid antagonist that can cause mucosal, gastrointestinal, hepatic or hematologic side effects) (Brion, Lambs, and Berthon 1985

Despite promising results from preclinical investigations, clinical studies often face issues related to poor bioavailability, inconsistent dosing, and methodological variability

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